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Description

Martins, F

Nat Commun 16 , 9547 (2025)

R., & Liu, D

, , ,

Cholesterol can induce PD-1 expression, impede CD8 + T cell proliferation, and diminish levels of toxic cytokines (such as TNF-, IFN-) by amplifying endoplasmic reticulum stress, thereby fostering immune evasion by tumor cells and functional impairment of CD8 + T cells